I hit a similar issue a few years ago where the mouse cursor would disappear in Excel. It turned out to be related to overlays in DWM.
Run the following command from PowerShell as Administrator, then reboot:
Set-ItemProperty -Path 'Registry::HKLM\SOFTWARE\Microsoft\Windows\Dwm' -Name OverlayTestMode 00000005
shell:startup, then right-click inside the Startup folder and select New > Shortcut to add a program.shell:appsfolder in the Run dialog box, then drag apps from that folder into the Startup folder.Some apps offer a 'run at startup' option, which is an easier way to add a program to startup in Windows 10.
When you hit the windows key, this option controls whether or not "Bing web search results are shown"
I personally don't want that search text going to the web
https://www.youtube.com/watch?v=ZNRY7aUfIpo
Windows + R -> regedit
Computer\HKEY_CURRENT_USER\SOFTWARE\Policies\Microsoft\Windows\Explorer
Make Explorer "Key"
Add 32-bit DWORD
DisableSearchBoxSuggestions, set it to 1 (hexadecimal)
Download AutoHotkey V2.0
Make an exe and have it autostart.
#Requires AutoHotkey >=2.0- <2.1
A_MaxHotkeysPerInterval := 200
^WheelDown::Return
^WheelUp::Return
Use REGEDIT to delete DLL that autostarts Logitech Options+ Dialog Box.
Windows+R then regedit
Navigate to Computer\HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Run
Name = Logitech Download Assistant
Data = C:\Windows\system32\rundll32.exe C:\Windows\System32\LogiLDA.dll,LogiFetch
Source: Reddit Comment